One line runs south out of Berlin, down the Elbe through Saxon Switzerland and across the border into Bohemia. Pick your travel day to see which of the direct trains actually run, where the line is cut, and how many hours you would really get in Prague if you came back the same evening.
Scheduled times checked on 7 September 2026, and the Monday engineering work on the German side of the border runs until 12 December 2026. Confirm your exact date before you book at int.bahn.de.